In recent years, Pitaya (Hylocereus spp.) has rapidly grown and developed in Taiwan with a production area growing from 900 ha to 2,500 ha over the last decade with annual export volume reaching to 110 tons. Meanwhile, the red pitaya is the most popular one in Taiwan, although hand pollination, unstable fruit size, cracking and serious diseases are the major weaknesses of the fruit. In order to upgrade the status of the country’s agriculture, the Council of Agriculture, Taiwan recently carried out the new agricultural policy, and we are looking forward to establishing a new paradigm for protecting farmers, agricultural development, and environmental sustainability through the principles of innovation, employment, distribution, and sustainability to stabilize the supply chain. This is being done to improve the quality of agricultural products, ensure the safety of agricultural products and consumer relief, enhance marketing promotion, and make agriculture step to a new milestone that is considered profitable and sustainable. Under the policy framework of establishing a new paradigm for agriculture, Taiwan will promote a friendly farming environment, sustainable agriculture resources, together with scientific and technological forces, to increase the market and value of agricultural products. This article will introduce the results and projects of pitaya in Taiwan under these policy guidelines, including achievements and ideas on breeding, cross-domain solution, post-harvest, and pests and diseases management.